Cassava Sciences (SAVA) Stock Climbs On Alzheimer’s Data

Cassava Sciences Inc (NASDAQ: SAVA) is flying in the market this morning, trading on early gains of more than 30%. The gains come after the company announced new promising data from an Alzheimer’s disease trial. Here’s what’s going on:

SAVA Gains On Clinical Data

In a press release issued early this morning, Cassava Sciences provided new data from a Phase 2a clinical study of PTI-125. The company is currently developing the treatment as a potential option for patients with Alzheimer’s disease.

In the release, SAVA said that the new data was presented by its scientists during a late-breaking oral presentation at the 12th International Conference on Clinical Trials on Alzheimer’s Disease.

Importantly, the company said that the new data show clinical evidence of the drug’s mechanism of action and drug-target engagement. This evidence includes:

  • Siomarker improvements in plasma and lyphocytes of Alzheimer’s disease patients.
  • Strong consistency across biomarker improvements in CFS, plasma, and lyphocytes.
  • A significant reduction in nitrated and phosphorylated forms of tau protein was observed.
  • Each individual patient showed improvement when treated with PTI-125.
  • The data also showed that PTI-125 reversed the shape of altered filamin A in lymphocytes.

With the positive data in mind, SAVA said that it expects to publish a manuscript of the new data in a peer-reviewed journal. In a statement, Remi Barbier, President and CEO at SAVA, had the following to offer:

Today’s data milestone is exciting because it provides additional support for the clinical benefits of slowing down both neurodegeneration and neuroinflammation in patients with Alzheimer’s

We’re eager to gain more insight on the effects of PTI-125 in Alzheimer’s after we conclude, in 2020, an on-going Phase 2b study.

Why This News Is So Exciting For Investors

Positive data is always exciting for a biotech investor. However, there’s good reason for the excitement aside from the fact that the data was positive. Here’s what’s going on:

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